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Clinical trials show IV glutathione at 600mg twice weekly reduces melanin index by 1522% over 812 weeks, while oral glutathione at 5001000mg daily shows 26% reduction or no measurable effect

Picardo, M

Whether IGF-1 LR3's prolonged receptor occupancy exacerbates this suppression more than native IGF-1 has not been studied directly, but the mechanism predicts a greater effect per unit time of receptor engagement [1, 18]

Danzer, J., Mellot, E., Bui, A.Q., Le, B.H., Martin, P., Hashimoto, M., Perez-Lesher, J., Chen, M., Pelletier, J.M., Somers, D.A., Goldberg, R.B., Harada, J.J., "Downregulating the expression of 53 soybean transcription factor genes uncovers a role for SPEECHLESS in initiating stomatal cell lineages during embryo development", Plant Physiology, M