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10.1038/emboj.2012.165 23 Kretz-RemyC.MehlenP.MiraultM

Patients develop early-onset neurological manifestations and neurodevelopmental disorders that are currently incurable (Falk, 2010)

The recommended approach is to aliquot the reconstituted solution into single-use portions before freezing, minimizing repeated thermal cycling of the main research stock

Clinical translation of ferroptosis modulators also faces significant bottlenecks, including bioavailability, limited tissue specificity, and potential toxicity or off-target [134, 135]