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Their mechanism of action is similar to the naturally occurring counterparts they are designed to mimic, i.e., to neutralize superoxide radical (O 2 ) and/or hydrogen peroxide (H 2 O 2 ) and convert them to water (Figure 3A)

The multiple concurrent complications of PCOS result in significant healthcare costs and clinical burdens

conditional ablation of GPX4 in adult mouse neurons leads to rapid paralysis and death due to the degeneration of motor neurons in the spinal cord, without evident degeneration in the cerebral cortex

Cultured mammalian cells were treated with menadione or BSO: menadione increases oxidation of glutathione, while BSO inhibits synthesis of cellular GSH

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