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In contrast, although it was identified ~65 years ago (40), PGLS has been a much-neglected enzyme, partly because the substrate 6-phospho--gluconolactone was thought to be unstable and to hydrolyze rapidly in a spontaneous manner (41)

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Fox, whose turn from Parkinson's disease patient to scientific crusader made him one of the country's most visible advocates for stem cell research, now believes the controversial therapy may not ultimately yield a cure for his disease, he told ABC's Diane Sawyer in an exclusive interview