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Notably, lignans exhibit anti-cancer activity through multiple regulatory pathways ( 3 Factors affecting the appropriate extraction methods for phenolic compounds Polyphenols comprise a broad array of chemical structures, resulting in varied chemical and physical properties ( Furthermore, extraction efficiency is highly sensitive to operational parameters such as pH, type of solvent employed, solvent-to-sample ratio, and duration of the extraction process ( 3.1 Extraction methods of phenolic compounds 3.1.1 Ultrasound-assisted extraction method Ultrasound-assisted extraction is a widely used and efficient technique for isolating phenolic compounds, offering high yields in a relatively short time ( The process relies on acoustic cavitation, wherein ultrasonic waves disrupt plant cell walls by inducing rapid expansion and contraction of solid surfaces ( Randia monantha , mango seed kernels, olive pomace, and pine needles ( Ultrasound-assisted extraction provides notable advantages for the extraction of polyphenols

Indeed, cancer progression is marked by characteristics such as sustained proliferative signaling, evasion of growth suppressors, resistance to apoptosis, angiogenesis, and metastasis, as well as inflammation and genomic instability (Hanahan and Weinberg 2017)

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BBB also provides protection to neural tissues against toxins and pathogens which may be present in circulation

2D, 2E and 2F)