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Consequently, wild-type p53 suppresses NADPH production, whereas tumor-associated p53 mutants show almost no activity in inhibiting G6PD, thereby maintaining a high level of NADPH production
Significantly enriched KEGG pathways are listed and gene symbols associated to NCBI accession numbers provided along with corresponding KEGG class and subclass from the BRITE hierarchy (colored circles correspond to subclasses from figure 1)

(01:12:04) Iron Load & Aging (01:15:05) Blood Work Analysis (01:19:37) C-Reactive Protein, Cholesterol: Serum & Dietary (01:26:02) Amino Acids, Plants, Antioxidants (01:33:45) Behaviors That Extend Lifespan, Testosterone, Estrogen (01:40:35) Neuroplasticity & Neural Repair (01:46:19) Ice Baths, Cold Showers, Metabolic Winter (01:48:07) Obesity & How It Accelerates Aging, GnRH (01:52:10) Methylation, Methylene Blue, Cigarettes (01:56:17) X-Rays (01:59:00) Public Science Education, Personal Health (02:05:40) The Sinclair Test You Can Take: www.doctorsinclair.com (02:08:13) Zero-Cost Support & Resources, Sponsors, Supplements, Instagram Title Card Photo Credit: Mike Blabac Disclaimer Day 52 The Science of Making & Breaking Habits | Episode 53 In this episode, I review the science of habit formation and habit elimination and how the process of neuroplasticity (brain rewiring) underlies these processes