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It is worldwide recognized as a diagnostic marker for many physiological diseases in humans (Yamada et al., 1991

doi: 10.1089/ars.2010.3547 34

Similarly, an in vitro study (Nan et al., 2014) using bovine mammary cells demonstrated that Lys, Met, and a combination of these amino acids (especially in a 3:1 Lys: Met ratio) positively regulated the expression of genes associated with the JAK2-STAT5 and mTOR pathway, and increased casein concentration, suggesting a potential effect on enhancing milk protein synthesis