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It also has to manage appetite, metabolic flexibility, and inflammation in a way that allows progress to continue long enough to become visible

Based on its localization in the cell, succinate can modulate different cellular pathways altering cell phenotype and function, as will be discussed in this section

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In a recent study, miR-126-3p has shown strong prognostic value in predicting long-term cardiovascular events by reflecting endothelial dysfunction, mainly through its association with albuminuria (161)

This forms a pathogenic positive feedback looplinking iron accumulation, A/tau pathology, and ferroptosiswhich collectively exacerbate neuronal injury (Yadav et al., 2023