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Medications Certain medications, such as acetaminophen and some antibiotics, can deplete glutathione levels by increasing oxidative stress

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Additionally, NLRP3 deficiency reduced cardiac damage by protecting the prolongation of the age-dependent PR interval, which is associated with AF [120]

Of note is the observation that one of the several proteases the schistosome gut produces for digestion of RBCs, cathepsin D, is also capable of cleaving IgG and complement component C3, although it is not known if this functions as an immune evasion technique for combatting gut permeabilization or is rather just part of digesting these factors as possible nutrient sources (167)

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