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Journal of Neurology, Neurosurgery, and Psychiatry 19(3):163-185

Velurajah R, Brunckhorst O, Waqar M, McMullen I, Ahmed K

doi: 10.1016/j.bjae.2020.04.006, 33

Neuroleptic drug-induced extrapyramidal syndromes and tardive dyskinesia

COMT inhibitors COMT inhibitors primarily function by inhibiting COMT, thereby increasing the concentration of L-DOPA in the brain and preventing its peripheral degradation into 3-O-methyldopa (3-OMD)