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Study has shown that Nrf2 is highly expressed in cancer tissues of NSCLC patients and can regulate the sensitivity of NSCLC cells to ferroptosis induced by Cys 2 deprivation [88]

Microbiota-derived metabolites are key mediators of host-microbe interactions ( 2.3 Bidirectional neuroendocrine crosstalk In addition to regulating host metabolism and immune responses, the gut microbiota is recognized to play a critical role in the production of neurotransmitters and engages in complex bidirectional communication with the hypothalamicpituitarygonadal (HPG) axis, contributing significantly to the pathogenesis and potential treatment of PCOS

However, in this GSH/GSSG couple, one form reduced glutathione or GSH is more important than the other

Materials and Methods Cell Culture U-87 MG cells were maintained in Eagles Minimum Essential Medium supplemented with 10% FBS and 1x pen-strep

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