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There is a significant correlation between the activity of reactive oxygen species (ROS) and the presence of transition metals like copper (Cu), iron (Fe), vanadium (V), nickel (Ni), and chromium (Cr) 41

The difference in recovery time is remarkablewhat used to take days now takes hours

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To enable nanoparticles to cross the BBB and reach the CNS specific targeting is needed [21, 25]

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