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Beyond the rumen, microbial communities inhabiting different segments of the gastrointestinal tract, as well as the respiratory tract, reproductive tract, mammary gland, and skin, collectively interact with the host to maintain homeostasis

However, it can lead to side effects, including immune cell death, bone marrow impairment, liver and kidney damage, cachexia (severe weight loss and muscle wasting), and secondary tumorigenesis

However, an exaggerated inflammatory response can lead to tissue damage and impaired healing

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The reaction proceeds in two steps, which occur at distinct active sites: one located at the N-terminal and the other at the C-terminal region of the enzyme