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Alongside B12 status, I consider all other factors that contribute to DVT risk and decide on the thromboprophylaxis approach based on the full picture

When these symptoms show up, higher doses of vitamin B12 may be needed to help

Delayed gastric emptying: A full stomach keeps the pyloric valve closed longer, preventing alcohol from reaching the small intestine where absorption is most rapid

This makes it an excellent candidate for research into gut inflammation, leaky gut, and other digestive system issues

Rare but serious risks include hypersensitivity reactions and herpes zoster (shingles) infections, which occurred in less than 3% of patients. Key Takeaway: The exceptional safety profile of severe asthma medication like mepolizumab allows long-term use without the organ damage, metabolic disruption, and immune suppression caused by chronic oral steroids