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183,184,185,186 Panobinostat, an oral broad-spectrum HDAC inhibitor approved in January 2015 for R/R MM in combination with dexamethasone and bortezomib, showed a slight overall survival benefit in phase II and III trials

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Research findings from full-length T4 studies cannot be assumed to apply directly to the fragment

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Hyland NP, O'Mahony SM, O'Malley D, O'Mahony CM, Dinan TG, Cryan JF (2015) Early-life stress selectively affects gastrointestinal but not behavioral responses in a genetic model of brain-gut axis dysfunction

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This tool, adapted from the Cochrane Collaborations RoB framework for use in preclinical animal research, allows systematic evaluation of potential sources of bias across ten domains grouped into five main categories: selection, performance, detection, attrition, and reporting bias

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