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Male Mc4r- KO mice were kept on a HFHS diet for 9 weeks and the mice were 17 weeks old at study start (The Jackson Laboratory, 032518)

Updated data including 11 patients with HER2 -mutant refractory NSCLC, showed an ORR of 72.7%, a median DoR of 9.9 months (95% CI, 6.9 to 11.5) and a median PFS of 11.3 months (95% CI, 8.1 to 14.3) [32]