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During the recovery phases, the release of oxygen-free radicals has been observed from many pathological stimuli and reached cerebral tissue (Snezhkina et al., 2020)

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Takahashi R, Kanda T, Komatsu M, Itoh T, Minakuchi H, Urai H, Kuroita T, Shigaki S, Tsukamoto T, Higuchi N, Ikeda M, Yamanaka R, Yoshimura N, Ono T, Yukioka H, Hasegawa K, Tokuyama H, Wakino S, Itoh H (2022) The significance of NAD + metabolites and nicotinamide N -methyltransferase in chronic kidney disease