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Recent studies on Long COVID and ME/CFS patients have revealed signs of elevated oxidative stress and aberrations in ROS clearance pathways, including elevated glutathione levels, decreases in mitochondrial superoxide dismutase, and lipid oxidative damage

PRXs are in high abundance and, therefore, are thought to be responsible for scavenging nanomolar levels of H 2 O 2 associated with signaling

Wang et al., 2015)

Neuroprotective effect of fraxetin and myricetin against rotenone-induced apoptosis in neuroblastoma cells

Adaptive immune dysregulation in PD appears to contribute to neuron loss: T cell infiltration and activation in the CNS correlates with more rapid disease progression