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Recently, ergothioneine received self-affirmed Generally Recognized As Safe (GRAS) and approval as a food supplement by the European Food Safety Authority (EFSA) [13], which led it to be a promising new functional food nutritive fortifier

Glossary ABH 2(S)-amino-6-hexanoic acid ACh acetylcholine ADMA asymmetric dimethylarginine Akt protein kinase B AMPK AMP-activated protein kinase ASL argininosuccinate lyase ASS argininosuccinate synthase BEC S-(2-boronoethyl)-l-cysteine BH 2 dihydrobiopterin BH 4 tetrahydrobiopterin CAD Coronary Artery Disease CaM calmodulin CaMKII calcium/calmodulin-dependent protein kinase II CAT-1 cationic amino acid transporter-1 Cav-1 caveolin-1 cGMP cyclic GMP CSD caveolin-scaffolding domain CVD cardiovascular disease CytB5R3 cytochrome b5 reductase 3 DHFR dihydrofolate reductase Dyn2 dynamin-2 ECs endothelial cells EDD end-diastolic diameter eNOS endothelial nitric oxide synthase FAD flavin adenine dinucleotide FMD% flow-mediated dilation percentage FMN flavin mononucleotide GPCR G-protein coupled receptor Grx1 glutaredoxin GSH reduced glutathione GSSG oxidized glutathione GTPCH guanosine triphosphate cyclohydrolase I Hb alpha subunit of hemoglobin HDL high-density lipoprotein HIF-1 hypoxia-inducible factor-1 alpha Hsp90 heat shock protein 90 ICAM-1 intracellular adhesion molecule 1 iNOS inducible NOS KLF2/KLF4 Krppel-like factor 2/Krppel-like factor 4 LAD left anterior descending coronary artery lncRNAs long non-coding RNAs LPS lipopolysaccharide MEJ myoendothelial junctions MI myocardial infarction METHF 5-methyltetrahydrofolate NADPH nicotinamide adenine dinucleotide phosphate NF-B nuclear factor kappa-light-chain-enhancer of activated B cells nNOS neuronal NOS NO nitric oxide NOHA N-hydroxy-L-arginine nor-NOHA N-hydroxy-nor-L-arginine NOS NO synthases NOSIP eNOS interacting protein NOSTRIN eNOS trafficking inducer NOX 2 NADPH oxidase 2 Nrf2 nuclear factor erythroid 2-related factor ox-LDL oxidized low-density lipoprotein PAH pulmonary arterial hypertension PDE phosphodiesterase PKA protein kinase A PKG protein kinase G PMCA plasma membrane Ca 2+ -ATPase PPIs protein-protein interactions PTMs post-translational modifications ROS reactive oxygen species sGC soluble guanylate cyclase SIRT1 sirtuin 1 SMAD2 mothers against decapentaplegic homolog-2 SNOs s-nitrosothiols SOCE store-operated Ca 2+ entry Sp1 specificity protein 1 Sp3 specificity protein 3 STIM1 stromal interaction molecule 1 T1D type 1 diabetes T2D type 2 diabetes TAC transverse aortic constriction TGF- tumor growth factor-beta TNF- tumor necrosis factor-alpha VEGF vascular endothelial growth factor VSMCs vascular smooth muscle cells References 1 AbdullaevI

The presence of funnel plot asymmetry also suggests potential publication bias, which warrants further scrutiny

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Interestingly, in the same way as T cells, thymic hormones (herein exemplified by thymosin, thymulin and thymopoietin), can circulate to impact immune cells and other cellular components in the periphery