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They provide multiple avenues through which changes in the gut microbiome can influence central processes relevant to neurodegeneration (and vice versa)

Zhang Y, Zhang L, Ban Q, Li J, Li CH, Guan YQ

92 Phosphorylation and activation of AMPK is in response to nutrients and AMP/ATP ratio through the upstream kinases serine/threonine kinase (LKB1) and calcium/calmodulin-dependent protein kinase (CaMKK)

Induction of c-Jun requires activation of c-Jun N-terminal kinase (JNK) through the phosphorylation on its Serine 63 and 73 residues

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