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DNA strand breaks induced apoptosis G2/M phase arrest and apoptosis often result from DNA damage in chemotherapy

In addition to its role in the glutathione redox cycle, riboflavin may directly act as an electron donor and reduce dehydroascorbate and tocopheroxyl radical to their active forms, the possible role which needs to be confirmed by future studies

Specifically, while a hydrophobic drug molecule on its own can diffuse into cells in large quantities, its conjugation to an antibody limits its uptake while also requiring an additional release step from the antibody in order to initiate a therapeutic effect

Mansouri K, Grulke CM, Judson RS, Williams AJ (2018) OPERA models for predicting physicochemical properties and environmental fate endpoints