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For post-simulation, trajectories were aligned to the protein backbone, and root mean square deviation (RMSD) was analyzed

doi: 10.1016/j.intimp.2024.113187 Summary Keywords gouty arthritis, disease staging, proteomics, validation, joint cavity effusion, tophi, ferroptosis Citation Xiao N, Lu H, Zeng S, Yan H, Yang Q, Sheng L, Chen B, Xu Y, Zhang J, Xie J, Zhou W, Li Z and Xie Z (2026) Exploring the inflammatory origins of gouty arthritis: mechanistic studies based on local lesion proteomics and validation

That means for every milligram you inject, roughly 0.8mg reaches systemic circulation in active form