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The fear of losing muscle alongside fat is legitimate, and it is one of the most searched concerns among people considering GLP-1 medications for weight loss

Lenvatinib administration also reduced mitochondrial carnitine-related and oxidative phosphorylation (OXPHOS) proteins in the skeletal muscle

At the same time, it should be emphasized that there is a lack of studies evaluating the comprehensive impact of EDs on the safety of pharmacotherapy and the risk of the occurrence of clinically significant drug interactions

The antioxidant activity of the resveratrol is exerted by its capacity to neutralize free radicals but also from its ability inactivating the antioxidant enzymes such as SOD, CAT, and GPx (Izzo et al., 2021)

Also, for Cd, the other heavy metal that we mentioned above, a direct relationship with thyroid autoantibodies was reported (53)