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Bioavailability Depletion-repletion pharmacokinetic experiments demonstrated that plasma vitamin C concentration is tightly controlled by three primary mechanisms: intestinal absorption, tissue transport, and renal reabsorption (22)

BMC Nephrol 22:15 Okuno S, Hashimoto K, Shimizu R, Takagi E, Kajiguchi T (2021) Development of autoimmune hemolytic anemia after BNT162b2 mRNA COVID-19 vaccination