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The Ca axis is associated with activation of phospholipase C or GMP-specific phosphodiesterase, followed by the release of intracellular Ca into the cytosol to activate downstream signaling proteins consisting of CREB and NFAT transcription factors mainly to regulate migration [90, 92]

[7] Localization or compartmentalization of activated proteins occurs in the presence of their given stimulus which creates local effects in the dendritic spine

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