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In an orthotopic pancreatic cancer model, this metabolic co-inhibition approach resulted in robust tumor suppression with minimal systemic toxicity (Fig

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In contrast, under oxidative stress conditions, ubiquitin ligase activity is blocked by modifying the cysteine residues in Keap1, thereby stabilizing and activating (Noguchi et al., 2018), stable NRF2 then translocates into the nucleus, binds to antioxidant response elements in the gene promoter region and regulates the transcription of a range of target genes involved in antioxidant defense and cellular redox maintenance (Ooi et al., 2018

Abeta induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss