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In another study they described a similar GSH reduction in red blood cells of sALS patients treated with insulin-like growth factor 1 (IGF-1), but probably only as a secondary cytotoxic effect due to the treatment with IGF-1 [103]

The Mann-Whitney test compared two groups, while the Kruskal-Wallis test with Dunns multiple comparison post-test was utilized for analyses involving multiple groups

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Mitochondrial ROS sources in diabetes As outlined above, the majority of molecular oxygen is processed by mitochondria involving four-electron reduction of dioxygen to water molecules