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For reproductive toxicity evaluation, Sprague Dawley rats (26 males and 26 females) received doses at 60, 180, or 540 mg/kg every 28 days (males on days 1, 29, and 57

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Initially, sepsis is driven by the recognition of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), which activate innate immune responses through pattern recognition receptors (Zhang et al., 2010