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Dark spots form when melanin production becomes uneven or excessive in certain areas (a process called hyperpigmentation)

From an evolutionary perspective, this shows that members of the NRT/PTR family have evolved to transport nitrate, defense compounds and plant hormones

doi: 10.1111/j.1528-1167.2006.00830.x 48

The three facilities warned are compounding pharmacies registered with the FDA as 503B outsourcing facilities. These pharmacies can manufacture and distribute large batches of drugs for sale to hospitals and clinics, and may also produce drugs to meet demand during a national drug shortage