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Exaggerated release of corticotropin-releasing factor (CRF) contributes to greater adrenocorticotropic hormone (ACTH) secretion and a subsequent elevation of circulating glucocorticoids (i.e., cortisol) (168)

Zimmermann, J., Oestreicher, J., Geissel, F., Deponte, M

While molecular mechanisms underlying ICD have been extensively studied, the clinical implications of ICD in disease classification, treatment, and prognosis remain underexplored

Furthermore, disease-related phenotypes were not observed in transgenic mice expressing human SOD1 that has multiple mutations including those at copper and zinc binding sites (H46R/H48Q/H63G/H71R/H80R/H120G) and two free Cys residues (C6G/C111S) with an ALS-linked mutation, H43R, and co-expression of wild-type human SOD1 did not cause the disease [35]

Johansson G, Mahller YY, Collins MH, Kim MO, Nobukuni T, Perentesis J, et al