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GLP-1 Receptor Activation : By activating GLP-1 receptors , Survodutide plays a key role in improving glucose control and insulin sensitivity , offering a promising direction for type 2 diabetes research and metabolic health

To obtain bacteriological sterility prior to conducting immunopeptidomics experiments, the cell pellet was lysed using 2x lysis buffer and complete protease inhibitor cocktail (Roche) for 30 minutes on ice, with periodic shaking every 10 minutes

Bcl-2 family proteins play a key role in the regulation of mitochondrial membrane permeability and the release of apoptosis factors, while caspase protease, especially Caspase-3, acts as an apoptosis effector molecule to activate downstream apoptosis-related proteins and destroy cytoskeleton and housekeeping gene functions