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Severe edema of the lamina propria and continuous diffuse edema of the submucosa, pronounced dilatation and stasis in the submucosal blood vessels were all markedly attenuated

aureus- infected macrophages in mice

This results in an overproduction of pro-inflammatory cytokines such as interleukin 6 (IL-6), tumour necrosis factor , adhesion molecules, prostaglandins, and mitogen-activated protein kinase signalling cascades