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As a result, the tissues and organs don't get enough oxygen, which can cause a wide range of symptoms

doi: 10.1016/j.molimm.2011.07.002 25

Although superoxide anion and hydrogen peroxide are not particularly reactive they may synergize with specific factors, eg iron, generating potent free radicals such as hydroxyl radical, which may cause direct injury through alteration of vital cellular macromolecules (DNA, protein or lipids)

Results showed that SHBG significantly enhanced mitochondrial flexibility, as indicated by the upregulation of MFN-1, PARKIN, and PINK genes

[DOI] [PMC free article] [PubMed] [Google Scholar] 123.Mkel M., Vaarala O., Hermann R., Salminen K., Vahlberg T., Veijola R., Hyty H., Knip M., Simell O., Ilonen J