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In contrast to chronic treatment with intact hGH, chronic treatment with AOD9604 showed no adverse effect on insulin sensitivity of the animals, as demonstrated with euglycemic clamp techniques Another study published in 2001 found the same thing, yet the results were very different for lean rats versus obese rats: Both hGH and AOD significantly reduced body weight gain in obese mice

Interestingly, compared to the use of autologous chondrocytes, both the use of autologous bone marrow and autologous adipose tissue was significantly shorter, with a median of 34 and 32 months, respectively

The underlying tissue is undergoing active remodeling

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