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Accumulation of free radicals and increased pro-inflammatory cytokines such as IL-1 and IL-6, combined with decreased expression of anti-inflammatory cytokines such as IL-10 and IL-4, contribute to the maintenance of the senescent inflammatory state (Ye and Johnson, 2001

It has demonstrated various pharmacological effects in both traditional medicine and modern medical research

When your blood carries less oxygen than it should, often because of low iron, vitamin B12, or folate, your muscles fatigue and ache more easily with normal use, including the muscles of your jaw

The 2,2-bipyridine may enter mitochondria and chelate mitochondrial iron, therefore decreasing the generation of ROS ( 2+ chelating agent, with coordination properties similar to 2,2-bipyridine

Furthermore, it can also ameliorate the oxidative stress induced by H2O2 in OB-6 osteoblast and improve the function of osteoblast [100]