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Similarly, attempts to boost BDNF levels via exercise or pharmacotherapy have yielded mixed results in AUD populations, partly due to individual differences in baseline neurotrophic reserves and genetic polymorphisms

J Neurosci 38 (30):66656681

(2018) used Transcription activator-like effector nucleases (TALENs) flanking a known NF1 nonsense mutation NF1 R1947 to transfect fetal Ossabaw minipig fibroblasts