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274(3): 11228 Marzo A, Martelli EA, Mancinelli A, et al

High GHRH-R Selectivity No GHS-R1a Cross-Reactivity Modified GRF (1-29) demonstrates high selectivity for GHRHR, with minimal cross-reactivity to other pituitary hormone receptors including the growth hormone secretagogue receptor (GHS-R1a) that mediates the effects of ghrelin and GHRPs such as Ipamorelin

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A companion study by Ng and colleagues in the Journal of Molecular Endocrinology examined AOD9401 in Zucker fatty rats and reported enzyme-level effects on hormone-sensitive lipase and acetyl-CoA carboxylase consistent with the dual antilipogenic and lipolytic model developed at Monash [4]