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In a study conducted by Signorile et al

Increased metabolic rate increases O 2 consumption and ROS generation

Individuals with risk factors for B12 deficiency including strict vegans, those with gastrointestinal conditions, patients taking long-term metformin or proton pump inhibitors, and older adultsshould discuss screening with their GP, even in the absence of obvious symptoms

Riboflavin supplementation resulted in clinical improvements in nine of ten patients treated [34,39-42,44,45]

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