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doi: 10.1038/tp.2011.60 270 MillerOShakespeare-FinchJBruenigDMehtaD

RET refers to a process where electrons flow in the opposite direction along the electron transport chain (ETC) compared with the typical oxidative phosphorylation process, leading to the generation of substantial amounts of ROS

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Studies with methodological ambiguities, insufficient experimental clarity, or conflicting results were excluded from the final synthesis to preserve the scientific integrity of the review