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In rodent models, a number of studies have found that GLP-/GIP dual agonists group mice have reduced fat mass, decreased circulating cholesterol, and lost weight, which has excellent weight loss effect

Funding KS thankfully acknowledges DST-SERB CRG for providing financial support in the form of research projects (No: EMR/2017/002841 and No: CVD/2020/000604) and the Central University of Punjab for the Research Seed Money (CUPB/Acad./2022/1194, Dated 19.05.2022) to conduct the study

Oral aspartame (75mg/kgbody weight/day) consumption causes oxidative stress in brain21 and its (40mg/kgbw/day) consumption caused oxidative stress in brain,22 liver and kidney,23 and also in immune organs.24 This inadequacy, combined with the general limited knowledge about the safety/potential toxigenic effects of substances widely present in the industrialized diet, motivated the design of the current study