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Additionally, it has been reported that the activation of TGR5 in monocytes and macrophages can reduce the production of pro-inflammatory cytokines and inhibit the expression of co-stimulatory molecules, suggesting that BAs play an immunomodulatory role through TGR5 [8,19]

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In a randomised, placebo-controlled study comparing the effects of erdosteine and NAC treatment for 10 days in 30 patients with mild-to-moderate COPD who were current smokers, both erdosteine and NAC caused significant reductions in ROS blood levels, but only erdosteine lowered 8-isoprostane levels and restored the short-term FEV 1 response to salbutamol [64]

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Der Wirkmechanismus von GHK-Cu beruht auf mehreren miteinander verknuepften Signalwegen