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A key role for actin-cytoskeletal disarrangement on these functional alterations has been proposed, since it has been causally linked to internalization of canalicular transporters and disarrangement of tight-junctional structures

Dead or dying epithelial cells release damage-associated molecular patterns (DAMPs), stimulate the recruitment of profibrotic macrophages, and enhance TGF- production in a self-amplifying loop (80)

(CSL) CSL, a member of the Cucurbitaceae family, is a widely cultivated edible vegetable, particularly in tropical regions of Africa, Asia, and South America

Glycolytic pathway affects differentiation of human monocytes to regulatory macrophages

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