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Like other polyphenols, Sal A can accept methyl groups from SAM and cause an elevation of homocysteine during the methionine-homocysteine cycle (Figure 1) [20]

However, evidence for an association between CAT gene polymorphism and ALD is currently lacking

The most extensive investigation to date into polymorphisms of genes encoding enzymes needed for estrogen metabolism and estrogen receptors as well as SNP associations with vasomotor symptoms and cardiovascular risk parameters is the Study of Women Across the Nation (SWAN)

*Correspondence: You-Wen He, [email protected]

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