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Lifestyle Genomics, 1-10

This loss of autophagy leads to an accumulation of ROS, which can exacerbate inflammation and eventually lead to carcinogenesis (Raju et al., 2012)

The proangiogenic phenotype of human tumor-derived endothelial cells depends on thrombospondin-1 downregulation via phosphatidylinositol 3-kinase/Akt pathway