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The 2024 Mendelian randomization study provides some causal inference for the depressionconstipation direction, but equivalent genetic instrument analyses for microbiota-disease causality remain limited by the low heritability of most microbial taxa

Mechanistically, lysosomal SLC1A2 mediates lysosomal glutamate and aspartate efflux to maintain V-ATPase activation, which sustains macropinocytosis and mTORC1 activation (144)

Acta Pharmacologica Sinica

Acknowledgments The authors would like to thank the barn staff at IRTA-Facilities, for taking care of the animal management and its support during sampling

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