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First of all, intracellular iron generally exists in the form of Fe 2+ , which can produce OH through the Fenton reaction, and then react with polyunsaturated fatty acids in the plasma membrane to produce ROS, resulting in iron-regulated death

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Peer review Peer review information Nature Communications thanks Weiqin Chen, Neil Kaplowitz, Hozumi Motohashi and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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