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Introduction Hyperpigmented macular freckling can occur as a single lesion (lentigo simplex) or as multiple lesions (benign vulvar melanosis)

They target different points in the chain, so the answer depends on what youre actually experiencing

These comparative studies establish the pharmacological basis for the different biological profiles of MT-1 versus MT-II , with MT-1s MC1R preference explaining its predominantly pigmentary and skin photoprotection biology in contrast to MT-IIs broader melanocortin receptor activation producing pro-sexual, pro-erectile, and central appetite effects alongside pigmentation

Research Published studies