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Similar evidence is found in patients with floxacillin-induced liver injury [169]

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Dysregulation of the Hippo signaling pathway, particularly through the inactivation of LATS1/2, results in the activation of YAP

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pmid:7744219 29

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Therefore, reactive astrocytes may not only produce fewer antioxidant molecules in the HD brain, but they might also release more pro-oxidant factors (Ben Haim et al., Furthermore, mHTT has been shown to reduce astrocytic release of BDNF (Wang et al., 2012

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