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10.3390/ijms23031387 29 LiZ.LuS.LiX

Catanzaro 2014) 5 Diagnosis Dry mouth and dry eyes (sicca symptoms) are key diagnostic symptoms in Sjgren syndrome, yet are often overlooked as unimportant by both patients and doctors (Brito-Zern 2016)

When it becomes oxidized, it can break down yielding a large variety of compounds including a, -unsaturated aldehydes (Poli et al., 1987) These are toxic compounds because they can react with proteins in the cells, particularly at cysteine, lysine or histidine by either Michael addition to the carboncarbon double bond or by Schiff base formation at the carbonoxygen double bond (Esterbauer et al., 1991

"The Informed Patient" is a podcast covering health, science and medicine, brought to you by Upstate Medical University in Syracuse, New York, and produced by Jim Howe, with sound engineering by Bill Broeckel and graphic design by Dan Cameron

Patients with preexisting cognitive impairment, such as those with mild cognitive impairment or Alzheimers dementia, exhibit a baseline brain energy gap due to impaired cerebral glucose metabolism