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Figure 3 Construction of GSTM1 and GSTT1 knockout mice To further investigate the mechanism by which GSTM1 and GSTT1 are involved in the pathogenesis of acute kidney injury (AKI), we successfully constructed mice with GSTM1 and GSTT1 knockout (GSTM1-KO and GSTT1-KO) using CRISPR-Cas9 technology

doi: 10.1007/978-981-10-9029-5_7 100 SunY.-L.HongS.-K

43 Several studies reported that Nrf2 and its transcriptional activity decline with increasing COPD severity 44-46 allowing for the hypothesis that sulforaphane may decrease oxidative stress and inflammation in COPD patients

Weight reduction may decrease that load and make activities such as walking, climbing stairs, and exercising more comfortable

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